Abstract by Kelton Forson
Chemistry and Biochemistry
Boron templated cyclization of allylic alcohols
We have discovered a new boron templated cascade reaction which acts on allylic alcohols to cyclize without expensive, toxic metal catalysts. This product can be easily hydrolyzed to give a diol product seen in natural products such as wutaienin. Upon optimization and examining the substrates tolerated by the reaction it was found that the reaction gave good to moderate yields for varying aromatic and non-aromatic allylic alcohols. Current research focuses on an enantioselective approach using a chiral boron compound.