BYU

Abstract by Jessie Payne

Personal Infomation


Presenter's Name

Jessie Payne

Degree Level

Undergraduate

Co-Authors

Eddie Lee
Jeremy Tsang

Abstract Infomation


Department

Chemistry and Biochemistry

Faculty Advisor

Kenneth Christensen

Title

CMG2 in Angiogenesis

Abstract

Angiogenesis, the formation of new blood vessels, plays a pathological role in many diseases such as cancer and corneal neovascularization.  Anti-angiogenic therapies are therefore of interest in the treatment of these and other diseases. Capillary Morphogenesis Gene 2 (CMG2) is a transmembrane cellular receptor that is shown to be upregulated in angiogenesis; in addition, inhibition of CMG2 leads to decreased angiogenesis in vivo.  Our lab has discovered that two crucial steps in angiogenesis- cellular adhesion and chemotactic migration across the extracellular matrix- can be significantly decreased upon competitive inhibition of CMG2. In addition, CMG2 KO cells showed limited ability to respond to migrate toward a serum gradient.  All of this points to CMG2 as a key player in the angiogenic process, and one that could be targeted in potential anti-angiogenic therapies.