Abstract by Connor Knight

Personal Infomation

Presenter's Name

Connor Knight

Degree Level



Jonard Corpuz Valdoz
Ronald Alejandro Zegarra

Abstract Infomation


Chemistry and Biochemistry

Faculty Advisor

Pam Van Ry


Cellular Transformation is Evident in the Induction of Lung Fibrosis


Idiopathic Pulmonary Fibrosis (IPF) is a progressive lung disease with its origin still unknown. In effort to identify the origin of IPF, we investigate connections between IPF and acid reflux as 90% of patients present this co-morbid disease. Our efforts are focused on the cellular transformation during IPF induction. Our data provide evidence that peptic activity initiates cell transformation from epithelial to mesenchymal—a cell type prevalent in IPF patient lungs. We believe this transformation is the basis of lung damage in patients. Our research provides ample evidence to this transformation and its effects on lung integrity. Ultimately, we aim to elucidate the mechanism of IPF genesis in hopes of finding effective therapeutic for those suffering from IPF.